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The Workshop on Molecular Evolution

Directors: David Hillis (University of Texas, Austin) and Mitch Sogin (Marine Biological Laboratory, Woods Hole)

Course Date: July 24 to August 3, 2011

Course Twitter feed Course Facebook Page

Now in its 24th year, the MBL's Workshop on Molecular Evolution at Woods Hole presents a series of lectures, discussions, and bioinformatic exercises that span contemporary topics in molecular evolution. The workshop encourages the exchange of ideas among leading theoreticians, software developers, and workshop participants. The workshop serves graduate students, postdoctoral students, and established faculty from around the world. The 2011 Workshop will use computer packages including AWTY, BEAST, Clustal W/X, FASTA, FigTree, GARLI, MIGRATE, LAMARC, MAFFT, MrBayes, PAML, PAUP*, PHYLIP, and SeaView to address the following topics:

  • Phylogenetic analysis: theoretical, mathematical, and statistical bases; sampling properties of sequence data; Maximum likelihood theory and practice; Bayesian analysis; hypothesis testing
  • Population genetics analysis using coalescence theory; maximum likelihood and Bayesian estimation of population genetic parameters
  • Databases and sequence matching: database searching: protein sequence versus protein structure; homology; mathematical, statistical, and theoretical aspects of sequence database searches; multiple alignment
  • Molecular evolution integrated at organism and higher levels: population biology; biogeography; ecology; systematics and conservation
  • Molecular evolution and development: gene duplication and divergence; gene family organization; coordinated expression in evolution
  • Comparative genomics: genome content; genome structure; genome evolution
  • Molecular evolution integrated at lower levels: biochemistry; cell biology; physiology; relationship of genotype to phenotype

Students will work with computer packages on their own laptops and have the opportunity to use the high performance computer clusters at the MBL.